NREM SLEEP STAGES SPECIFICALLY ALTER DYNAMICAL INTEGRATION OF LARGE-SCALE BRAIN NETWORKS


Guadecitabine plus ipilimumab in unresectable melanoma: five-year follow-up and integrated multi-omic analysis in the phase 1b NIBIT-M4 trial

Abstract Association with hypomethylating agents is a promising strategy to improve the efficacy of immune checkpoint inhibitors-based therapy.The NIBIT-M4 was a phase Ib, dose-escalation trial in patients with advanced melanoma of the hypomethylating agent guadecitabine combined with the anti-CTLA-4 antibody ipilimumab that followed a traditional

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Genomic Characterisation of a Highly Divergent Siadenovirus (Psittacine Siadenovirus F) from the Critically Endangered Orange-Bellied Parrot (Neophema chrysogaster)

Siadenoviruses have been detected in wild and captive birds worldwide.Only nine siadenoviruses have been fully sequenced; however, partial sequences for 30 others, many of these from wild Australian birds, are also described.Some siadenoviruses, e.g., the turkey siadenovirus A, can cause disease; however, most cause subclinical Nets infections.An e

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Exploring the Effects of Carbon Pricing and Carbon Quota Control on the Energy Transition Towards Carbon Neutrality: A Computable General Equilibrium Analysis of the Zhejiang Region of China

The pathway towards carbon neutrality in regions with a relatively light industrial structure and scarce renewable energy resources presents a challenge Side Cover when balancing energy efficiency improvements with the expansion of renewable energy.Therefore, this study investigates the effectiveness of carbon pricing and carbon quota control as re

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